Aortic & peripheral vascular diseaseCohort study
Age at first cardiovascular diagnosis and risk of subsequent cardiovascular events in patients with different types of cardiovascular disease
- Prospective cohort study
- UCC-SMART study
- Cox proportional hazards models adjusted for classical risk factors
- stratified by sex
Authors' conclusion
Younger age at first CVD diagnosis is related to lower risk of subsequent cardiovascular events in men and women with CeVD and women with PAD/AAA, but not in men and women with CAD and men with PAD/AAA.
Study context
- Population
- Patients with a recent (<12 months) first cardiovascular disease (CVD) diagnosis: Coronary artery disease (CAD), cerebrovascular disease (CeVD), or PAD or AAA (PAD/AAA)1,595 subsequent CV events
- Participants
- 5,057 patients
- Exposure
- Higher vs lower age at first CVD diagnosis, by CVD subtype and sex
- Outcome
- Subsequent CV event:
- MI and coronary interventions
- Stroke
- Major adverse limb events
- CV death
- Follow-up
- Median 11.0 years (IQR 5.8-16.1)
Main finding
As reported in the abstract
Subsequent CV event, by CVD subtype and sex · median follow-up 11.0 years
age at CVD diagnosisHR per 10-year increase (95% CI)
CeVD, men
2.78(2.11–3.68)
CeVD, women
1.56(1.33–1.83)
PAD/AAA, women
1.57(1.30–1.90)
Observational data: associations, not effects.
Original publication
Age at first cardiovascular diagnosis and risk of subsequent cardiovascular events in patients with different types of cardiovascular disease. Eur J Prev Cardiol. Published 2 February 2026. doi:10.1093/eurjpc/zwag073
Summarised from the published abstract; every number is checked against it