Heart failure & cardiomyopathiesCohort study
Age at Onset of Heart Failure and Subsequent Risk of Dementia
- Prospective cohort study
- propensity-score matched
Authors' conclusion
Younger age at HF onset was associated with increased risk of dementia.
Study context
- Population
- UK Biobank participants
- Participants
- 14,413 vs 442,791
- Exposure
- Heart failure (HF) vs no HF
- HFn = 14,413
- Without HFn = 442,791reference
- Outcome
- Incident all-cause dementia, AD and VD by age at HF onset
Main finding
As reported in the abstract
All-cause dementia, AD and VD by age at HF onset
HR
- HF vs Without HF · all-cause dementia
- 1.14
- HF · all-cause dementia per 10-year decrease in age at HF onset, multivariable-adjusted
- 1.18
- HF · Alzheimer disease (AD) per 10-year decrease in age at HF onset, multivariable-adjusted
- 1.64
- HF · vascular dementia (VD) per 10-year decrease in age at HF onset, multivariable-adjusted
- 1.27
- HF onset ≥75 years vs Matched controls · all-cause dementia, propensity-score matched
- 1.05
- HF onset 65-74 years vs Matched controls · all-cause dementia, propensity-score matched
- 1.10
- HF onset <65 years vs Matched controls · all-cause dementia, propensity-score matched
- 1.67
Observational data: associations, not effects.
Original publication
Age at Onset of Heart Failure and Subsequent Risk of Dementia. JACC Heart Fail. Published 27 September 2023. doi:10.1016/j.jchf.2023.08.006
Summarised from the published abstract; every number is checked against it