Heart failure & cardiomyopathies
Age- and sex-related differences in heart failure characteristics and treatment patterns across the ejection fraction spectrum: first data from the BRING-UP 3 Heart Failure study
Authors' conclusion
Significant age- and sex-related disparities exist in HF characteristics and treatment patterns. Tailored management strategies are needed to optimize medical therapy for females and older adults, to improve HF outcomes and ensure equitable care.
Study context
- Population
- All-comers cohort of heart failure (HF) patients at Italian cardiology sitesHF patients (median age 72 years, 24% female) included over three months
- Participants
- 5,203 participants
- Exposure
- Age- and sex-related differences in clinical characteristics and treatments
- Outcome
- Clinical characteristics and OMT by sex
Methodological details179 Italian cardiology sites, all-comers cohort
- 179 Italian cardiology sites
- All-comers cohort
Main finding
As reported in the abstract
- Females were older, had a higher prevalence of non-ischemic HF etiologies, and were less likely to receive optimal medical therapy (OMT) compared with males
Observational data: associations, not effects.
Further findings
| Outcome | Odds ratio (95% CI) |
|---|---|
| Receiving OMT (multivariable adjustment)After multivariable adjustment | 0.94 (0.88–0.93) |
- Receiving OMT (multivariable adjustment): only age remained independently associated with a lower likelihood of receiving OMT
OMT by age
- Older patients also experienced suboptimal treatment
Original publication
Age- and sex-related differences in heart failure characteristics and treatment patterns across the ejection fraction spectrum: first data from the BRING-UP 3 Heart Failure study. Eur Heart J Qual Care Clin Outcomes. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →