Age-stratified patterns in clinical presentation, treatment and outcomes in acute pericarditis: a retrospective cohort study
Main finding · RecurrencesResult — go to the resultHazard ratio 3.23 95% CI 1.81–5.58Authors' conclusion
Older age is associated with less recurrences of pericarditis, but more severe complications with need for hospitalisation.
Study context
- Population
- Patients with a first episode of acute pericarditis, January 2014 to June 2022median age 56.3 years
- Participants
- 471 patients
- Exposure
- Age groups
- Outcome
- Recurrences
Methodological detailsconsecutive enrolment
- Consecutive enrolment
Main finding
As reported in the abstract
Hazard ratio
3.23
95% CI 1.81–5.58
P < 0.001
By group
Younger age
HR 3.23 (95% CI 1.81–5.58); P < 0.001
- Recurrences differed across age groups
- P < 0.001
Observational data: associations, not effects.
Further findings
Clinical presentation and treatment, younger (G1-G2-G3) vs older (G4)
- Younger: more chest pain, pericardial rubs
- P < 0001
- Younger: more ECG changes
- P = 0.002
- Younger: more often treated with colchicine
- P < 0.001
- Younger: more often treated with NSAIDs
- P = 0.006
- Older (G4): more dyspnoea, pericardial/pleural effusion
- P = 0.007
- Older (G4): more often treated with corticosteroids
- P = 0.037
Secondary cause of pericarditis
- Secondary cause detected
- 128/471 (27.2%)
Safety
Complications in older vs younger patients
- Older: more new-onset AF
- P < 0.001
- Older: more cardiac tamponade
- P = 0.005
- Older: more commonly hospitalised
Original publication
Age-stratified patterns in clinical presentation, treatment and outcomes in acute pericarditis: a retrospective cohort study. Heart. Published 26 June 2024. doi:10.
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