Heart failure & cardiomyopathiesCohort study
Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure
- retrospective multicenter cohort study
Authors' conclusion
Although CPET parameters were associated with adverse outcomes across age groups, the prognostic contribution of peak VO2 was most pronounced in older patients with HF, highlighting the importance of CPET-based risk stratification in this population.
Study context
- Population
- Patients with heart failure (HF) who underwent cardiopulmonary exercise testing (CPET), examined in 3 age groupspatients with HF who underwent CPET
- Participants
- 830 patients
- Exposure
- age-stratified prognostic value of CPET parameters for adverse outcomes in patients with HF
- Outcome
- composite of:
- All-cause death
- HF hospitalization
- Follow-up
- Within 3 years
Main finding
As reported in the abstract
patients experienced adverse outcomes
176/830
Observational data: associations, not effects.
Further findings
| Outcome | 20 to 64 | 65 to 79 | ≥80 years |
|---|---|---|---|
| Peak VO2 and adverse outcomes | Not reported in the abstract | Not reported in the abstract | HR 0.72 (95% CI 0.62–0.85) |
| Area under the curve of peak VO2 · tended to increase with age | Not reported in the abstract | Not reported in the abstract | AUC 0.81 (95% CI 0.70–0.91) |
| Area under the curve of VE/VCO2 slope · comparable across age groups | Not reported in the abstract | Not reported in the abstract | AUC 0.68 (95% CI 0.55–0.81) |
- Peak VO2 and adverse outcomes: 65-79 years HR 0.90 (95% CI 0.84–0.96)
- Peak VO2 and adverse outcomes: associated with adverse outcomes in patients 65 years or older
- Area under the curve of peak VO2: 20-64 years AUC 0.61 (95% CI 0.53–0.69)
- Area under the curve of peak VO2: 65-79 years AUC 0.74 (95% CI 0.67–0.81)
- Area under the curve of VE/VCO2 slope: 20-64 years AUC 0.64 (95% CI 0.56–0.72)
- Area under the curve of VE/VCO2 slope: 65-79 years AUC 0.68 (95% CI 0.60–0.76)
VE/VCO2 slope and adverse outcomes
- consistently associated across age groups
- P < 0.05 for all
Original publication
Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure. JACC Adv. Published 15 July 2026. doi:10.1016/j.jacadv.2026.103008
Summarised from the published abstract; every number is checked against it