Prevention & lipidsCohort study
Ages at coronary heart disease and death in familial hypercholesterolaemia: a Danish nationwide study spanning 44 years
- Retrospective cohort study
- nationwide registries
Authors' conclusion
Nationwide from 1978 to 2021 in Denmark, normalization of age at death but not age at coronary heart disease was observed for individuals diagnosed with familial hypercholesterolaemia.
Study context
- Population
- All Danish residents, nationwide registries, 1978–2021
- Participants
- 10,199 vs 9,174,926
- Exposure
- Familial hypercholesterolaemia vs no familial hypercholesterolaemia
- with familial hypercholesterolaemian = 10,199
- without familial hypercholesterolaemian = 9,174,926reference
- Outcome
- Trends over time in age at death and age at CHD
- Follow-up
- 1978 to 2021
Main finding
As reported in the abstract
Age at death 22 years younger with vs without FH in 1978
P < .001
Age at death similar with vs without FH in 2021
P = .16
Age at CHD 20 years younger with vs without FH in 1978
P < .001
Age at CHD still 7 years younger with vs without FH in 2021
P < .001
Observational data: associations, not effects.
Further findings
Death and CHD during follow-up
Died
CHD
Sex subgroups and 1:100 matched analysis (sex, ethnicity, time of birth)
- Results similar in women and men and in the matched analysis
- matched analysis 1:100
Original publication
Ages at coronary heart disease and death in familial hypercholesterolaemia: a Danish nationwide study spanning 44 years. Eur Heart J. Published 17 January 2025. doi:10.1093/eurheartj/ehae912
Summarised from the published abstract; every number is checked against it