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Arrhythmias & electrophysiologyCohort study

Aggressive ablation vs. regular ablation for persistent atrial fibrillation: a multicentre real-world cohort study

EuropacePublished

  • Retrospective cohort study
  • multicentre
  • propensity-score matched
  • 10 centres
Read the original article ↗

Authors' conclusion

Aggressive ablation achieved more favourable outcomes than regular ablation, and moderately aggressive ablation may be associated with better clinical outcomes.

Study context

Population
Patients with persistent AF undergoing catheter ablationPropensity score (PS)-matched 1560 each
Participants
4,833 patients
Exposure
Aggressive ablation vs regular ablation
  • Aggressiven = 1,560
  • Regularn = 1,560reference
Outcome
AF/AT recurrence-free survival off anti-arrhythmic drugs after a single procedure
Follow-up
12 months

Main finding

AF/AT-free survival

Hazard ratio

0.745

P < 0.001

By group

As reported in the abstract

Observational data: associations, not effects.

Further findings

AT recurrence · 12 months

P = 0.539

Procedural AF termination

P < 0.001

OutcomeAggressiveRegularP value
AF/AT-free survival, with vs without AF terminationP < 0.001
AF/AT-free survival, anatomical vs PVI-only (within regular, PS-matched n = 455 each)P = 0.122
AF/AT-free survival, aggressive vs anatomical alone (PS-matched n = 1362 each)67.5%Not reported in the abstractP < 0.001
  • AF/AF/atrial tachycardia (AT)-free survival, with vs without AF termination: AF termination 72.3%
  • AF/AT-free survival, with vs without AF termination: No AF termination 55.2%
  • AF/AT-free survival, anatomical vs PVI-only (within regular, PS-matched n = 455 each): Anatomical 60.7%
  • AF/AT-free survival, anatomical vs PVI-only (within regular, PS-matched n = 455 each): PVI-only 55.6%
  • AF/AT-free survival, aggressive vs anatomical alone (PS-matched n = 1362 each): Anatomical 59.9%

Safety

Safety endpoints

Did not differ significantly between the two groups

Original publication

Aggressive ablation vs. regular ablation for persistent atrial fibrillation: a multicentre real-world cohort study. Europace. Published 6 March 2025. doi:10.1093/europace/euaf045
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it