Aortic & peripheral vascular diseaseCohort study
Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study
- Prospective cohort study
Authors' conclusion
In this study, long-term air pollutants exposure was associated with an increased risk of AAA incidence.
Study context
- Population
- UK Biobank participants
- Participants
- 449,463 participants
- Exposure
- Long-term air pollutant exposure and genetic susceptibility in relation to abdominal aortic aneurysm (AAA) risk
- Outcome
- Incident AAA
Main finding
As reported in the abstract
AAA incidence per pollutant (long-term exposure)
Hazard ratio (95% CI)
PM2.5
1.21(1.16–1.27)
PM10
1.21(1.16–1.27)
NO2
1.16(1.11–1.22)
NOx
1.10(1.05–1.15)
Per pollutant, as printed
Observational data: associations, not effects.
Further findings
Joint association of air pollutant exposure and genetic risk with AAA incidence (high exposure + high genetic risk vs low exposure + low genetic risk)
| Comparison | HR (CI) | |
|---|---|---|
| PM2.5 | 3.18 (2.46–4.12) | |
| PM10 | 3.09 (2.39–4.00) | |
| NO2 | 2.41 (1.86–3.13) | |
| NOx | 2.01 (1.55–2.61) | |
| 0.20.5125Hazard ratio (log scale) |
- Joint association of air pollutant exposure and genetic risk with AAA incidence (high exposure + high genetic risk vs low exposure + low genetic risk): high exposure + high genetic risk vs low exposure + low genetic risk
- Joint association of air pollutant exposure and genetic risk with AAA incidence (high exposure + high genetic risk vs low exposure + low genetic risk): high exposure + high genetic risk vs low exposure + low genetic risk
- Joint association of air pollutant exposure and genetic risk with AAA incidence (high exposure + high genetic risk vs low exposure + low genetic risk): high exposure + high genetic risk vs low exposure + low genetic risk
- Joint association of air pollutant exposure and genetic risk with AAA incidence (high exposure + high genetic risk vs low exposure + low genetic risk): high exposure + high genetic risk vs low exposure + low genetic risk
AAA risk with low-level air pollutant exposure
- Detrimental effects of air pollutants persisted even with low-level exposure
Original publication
Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study. Eur Heart J. Published 18 January 2024. doi:10.1093/eurheartj/ehad886
Summarised from the published abstract; every number is checked against it