Heart failure & cardiomyopathies
Albuminuria is Associated with Worse Outcomes in Non-Diabetics Hospitalized with Acute Heart Failure
Authors' conclusion
Albuminuria is largely not associated with the risk of death, cardiovascular death, or HF hospitalization in AHF, except admission UACR is associated with the risk of death in non-diabetics.
Study context
- Population
- Patients hospitalised with acute heart failure (HF) in ROSE-AHFbaseline urinary albumin-to-creatinine ratio (UACR)
- Participants
- 339 patients
- Comparison
- Baseline, Day 7 and change in UACR
- Primary endpoint
- All-cause mortality; composite of first HF hospitalisation or CV mortality
- Follow-up
- 6 months (mortality); 2 months (composite)
Primary result
As reported in the abstract
Deaths
65
HF hospitalisations or CV deaths
82
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality by baseline UACR, non-diabetics (subgroup)Not associated in diabetics | 2.58 (1.00–6.66) | P = 0.050 | |
| 0.10.31310Hazard ratio (log scale) |
- All-cause mortality by baseline UACR, non-diabetics (subgroup): interaction by diabetes status P = 0.022
Day 7 UACR and change in UACR
- Neither Day 7 UACR nor change in UACR associated with outcomes
Original publication
Albuminuria is Associated with Worse Outcomes in Non-Diabetics Hospitalized with Acute Heart Failure. ESC Heart Fail. Published 12 November 2025. doi:10.
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