Alcohol septal ablation in patients aged 75 years or older with hypertrophic obstructive cardiomyopathy

doi:10.1136/heartjnl-2023-322659

Heart failure & cardiomyopathies

Alcohol septal ablation in patients aged 75 years or older with hypertrophic obstructive cardiomyopathy

HeartPublished 17 Jul 2023Retrospective cohort study

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Authors' conclusion

ASA had similar efficacy and intrahospital mortality in patients ≥75 years compared with younger patients.

Study context

Population: Patients with hypertrophic obstructive cardiomyopathy (HOCM) and left ventricular outflow tract gradients (LVOTG) ≥50 mm Hg undergoing alcohol septal ablation, 1997–2021
Participants: 208 vs 1,430

Exposure: Alcohol septal ablation (ASA) in patients ≥75 years vs <75 years
≥75 yearsn = 208
<75 yearsn = 1,430reference

Methodological detailssingle-centre

Single-centre

Main finding

As reported in the abstract

Exercise-induced LVOTG · follow-up (6 months)

≥75 years29.5IQR 18.0–54.0 · mm Hg

<75 years39.5IQR 23.0–73.8 · mm Hg

P = 0.0007

Observational data: associations, not effects.

Further findings

6-min walk distance · baseline

P < 0.0001

≥75 years317.0 mIQR 242.0–389.0

<75 years438.0 mIQR 353.3–504.0

In-hospital mortality

P = 0.6580

≥75 years1.0%

<75 years0.6%

Safety

High-degree AV block after ASA

P < 0.0001

≥75 years25.5%

<75 years13.6%

Original publication

Alcohol septal ablation in patients aged 75 years or older with hypertrophic obstructive cardiomyopathy. Heart. Published 17 July 2023. doi:10.1136/heartjnl-2023-322659

Read the original article ↗PubMed

Summarised from the published abstract; every number is checked against it