Cardiometabolic & kidneyCohort study
Alcohol use disorder and cardiovascular risk in type 2 diabetes: beyond alcohol consumption
- Retrospective cohort study
- nationwide database
Authors' conclusion
In adults with T2D, AUD was associated with increased risk of incident MACE, even after adjustment for self-reported alcohol consumption volume.
Study context
- Population
- Adults with T2D who underwent national health screening in 2012, Korean National Health Insurance Service database
- Participants
- 364,950 adults
- Exposure
- Alcohol use disorder (AUD) vs no AUD
- AUDn = 4,888
- non-AUDn = 360,062reference
- Outcome
- Incident MACE:
- MI
- Ischaemic stroke
- CV death
- Follow-up
- Median 10.2 years
Main finding
Incident MACE
Hazard ratio
1.70
95% CI 1.59–1.82
AUD vs non-AUD
HR 1.70 (95% CI 1.59–1.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CV death | 2.37 (2.06–2.72) | |
| MACE by alcohol consumption (subgroup) · low-risk drinkers | 1.44 (1.30–1.61) | |
| MACE, age 40-64 years (subgroup) · most pronounced association | 1.89 (1.75–2.05) | |
| 0.20.5125Hazard ratio (log scale) |
- Major adverse cardiovascular events (MACE) by alcohol consumption (subgroup) — With AUD, risk elevated across all levels of alcohol intake
- all P < 0.001
MACE by alcohol consumption (subgroup)
- J-shaped association between alcohol consumption and MACE without AUD
Original publication
Alcohol use disorder and cardiovascular risk in type 2 diabetes: beyond alcohol consumption. Eur J Prev Cardiol. Published 25 September 2026. doi:10.1093/eurjpc/zwag455
Summarised from the published abstract; every number is checked against it