Valvular & structural heart disease
Alerting trends in epidemiology for calcific aortic valve disease, 1990–2019: An age–period–cohort analysis for the Global Burden of Disease Study 2019
Authors' conclusion
Although CAVD mortality reduction was observed globally, unfavourable period, and cohort effects were found in many countries. Increase of mortality rate among the population ≥85 years was the common challenge across all SDI quintiles
Study context
- Population
- Global population, calcific aortic valve disease (CAVD), 1990–2019
- Exposure
- Socio-demographic index (SDI) quintiles, age, period and birth cohort
- Outcome
- Trends in CAVD mortality and its leading risk factors by age, period and birth cohort
- Follow-up
- 1990–2019
Main finding
As reported in the abstract
Trend in CAVD mortality
High SDI
−1.45%
95% CI −1.61–-1.30
High-middle SDI
0.22%
95% CI 0.06–0.37
- Global CAVD deaths in 2019
- 127 000
Observational data: associations, not effects.
Further findings
Period and birth cohort effects (high SDI countries)
- Favourable period effect
- 0.69 (95% CI 0.66-0.72)
- Favourable birth effect
- 0.30 (95% CI 0.22-0.43)
- Unfavourable effects mostly in high-middle SDI countries
Leading risk factor of CAVD deaths
- High SBP was the leading risk factor globally, with favourable trends in high SDI regions
Original publication
Alerting trends in epidemiology for calcific aortic valve disease, 1990–2019: An age–period–cohort analysis for the Global Burden of Disease Study 2019. Eur Heart J Qual Care Clin Outcomes. Published 9 March 2023. doi:10.
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