Cardio-oncology & otherCross-sectional study
All-Cause and Disease-Specific Mortality Among U.S. Adults Living With Co-Existing Cancer and Atherosclerotic Cardiovascular Disease
- National Health Interview Survey (2005-2018) linked to the National Death Index
- multivariable-adjusted Cox proportional hazards models
Authors' conclusion
Among community-dwelling U.S. adults living with cancer and/or ASCVD, co-existing disease was associated with substantially higher mortality. These findings highlight the elevated burden of mortality among individuals with co-existing cancer and ASCVD and underscore the importance of integrated cardio-oncology care.
Study context
- Population
- U.S. adults aged ≥18 years living with cancer, atherosclerotic cardiovascular disease (ASCVD), co-existing cancer and ASCVD, or neither1.3% had co-existing cancer and ASCVD
- Participants
- 388,632 adults
- Exposure
- Mortality outcomes were compared across individuals with cancer alone, ASCVD alone, and co-existing conditions, relative to those with neither condition.
Main finding
As reported in the abstract
All-cause mortality · mean follow-up of 7.2 years
Each group vs neither conditionaHR
co-existing cancer and ASCVD
2.45(95% CI 2.23–2.70)
ASCVD alone
1.93(CI 1.82–2.04)
cancer alone
1.90(CI 1.77–2.04)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| Cancer mortality and cardiovascular mortality — co-existing cancer and ASCVD vs neither condition · cancer mortality | 4.18 (3.48–5.03) | |
| Cancer mortality and cardiovascular mortality — co-existing cancer and ASCVD vs neither condition · cardiovascular mortality | 2.73 (2.30–3.24) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Factors associated with all-cause mortality among those living with co-existing diseases
- older age (≥75 years) aHR
- 6.02 [1.97-18.37]
- diabetes aHR
- 1.23 [1.03-1.46]
- current/former smoking status aHR
- 1.26 [1.07-1.49]
Estimated U.S. adults with co-existing cancer and ASCVD
- approximately U.S. adults annually
- 3.0 million
Original publication
All-Cause and Disease-Specific Mortality Among U.S. Adults Living With Co-Existing Cancer and Atherosclerotic Cardiovascular Disease. JACC Adv. Published 20 July 2026. doi:10.1016/j.jacadv.2026.103035
Summarised from the published abstract; every number is checked against it