Acute cardiac care & resuscitationCohort study
Amiodarone After Conversion From a Non-shockable to a Shockable Rhythm in Out-of-Hospital Cardiac Arrest A Propensity Score-Matched Analysis from the German Resuscitation Registry
- retrospective observational cohort study
- Propensity-score-matched patient pairs (1:1)
Authors' conclusion
In OHCA patients with an initial non-shockable rhythm who subsequently converted to a shockable rhythm, amiodarone administration was associated with improved short-term and long-term survival, but not with a statistically significant improved favourable neurological outcome. Future controlled studies might define the proper (earlier) time of amiodarone administration.
Study context
- Population
- Adult patients with non-traumatic OHCA, having an initial non-shockable rhythm and subsequently received at least two defibrillations, German Resuscitation Registry1,843 patients in each group after propensity-score matching
- Participants
- 5,535 patients
- Exposure
- patients who received amiodarone during resuscitation and those who did not
- amiodaronen = 1,843
- no amiodaronen = 1,843reference
- Outcome
- survival to hospital discharge
- Follow-up
- Hospital discharge
Main finding
As reported in the abstract
Odds ratio
1.58
95% CI 1.18–2.12
By group
amiodarone vs no amiodarone
OR 1.58 (95% CI 1.18–2.12)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | amiodarone | no amiodarone | OR (95% CI) | |
|---|---|---|---|---|
| hospital admission with ROSC | 26.7% | 23.0% | 1.22 (1.05–1.42) | |
| 24-hour survival | 21.4% | 14.7% | 1.58 (1.33–1.87) | |
| Favourable neurological outcome at hospital discharge · not statistically significant | 3.7% | 2.9% | 1.31 (0.91–1.89) | |
| 0.512Odds ratio (log scale) |
Original publication
Amiodarone After Conversion From a Non-shockable to a Shockable Rhythm in Out-of-Hospital Cardiac Arrest A Propensity Score-Matched Analysis from the German Resuscitation Registry. Resuscitation. Published 6 October 2026. doi:10.1016/j.resuscitation.2026.111349
Summarised from the published abstract; every number is checked against it