HypertensionCohort study
An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses
- Prospective cohort study with exposome-wide association and genetic analyses
- discovery and replication datasets
- meta-analyses
- LDSC
- two-sample Mendelian randomization
- Up to 10 806 exposome variables in 13 categories
Authors' conclusion
This study provides an atlas on established and novel risk factors for hypertension, underpinned by epidemiological and causal evidence.
Study context
- Population
- UK Biobank participants free of hypertension at baseline
- Participants
- 214,957 participants
- Outcome
- Incident hypertension
Main finding
As reported in the abstract
Exposures associated with incident hypertension
- Exposome variables significant in exposome-wide association studies (ExWAS) and replicated
- 964
- Backed by convincing and highly suggestive evidence in meta-analyses
- 462
- Exposures with global genetic correlation with hypertension (of 10 765 in LDSC)
- 1923
- Mendelian randomization (MR) robust evidence of causal relationship (phenotypes)
- 125
- MR probable evidence (phenotypes)
- 270
- MR suggestive evidence (phenotypes)
- 718
- Associations supported by strong epidemiological and genetic evidence in co-analyses
- 146
Observational data: associations, not effects.
Original publication
An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses. Eur J Prev Cardiol. Published 18 July 2024. doi:10.1093/eurjpc/zwae236
Summarised from the published abstract; every number is checked against it