Heart failure & cardiomyopathiesDiagnostic or prognostic study
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score
- Diagnostic accuracy study
- derivation and validation cohorts
- international, multicenter validation cohort
Authors' conclusion
Using the HFpEF-ABA score, rapid and efficient screening for risk of undiagnosed HFpEF can be performed in patients with dyspnea using only age, body mass index and history of atrial fibrillation.
Study context
- Population
- Patients evaluated for heart failure with preserved ejection fraction (HFpEF) (dyspnea), derivation and validation cohortsderivation cohort
- Participants
- 414 patients
- Outcome
- Discrimination (AUC) of the HFpEF-ABA score for HFpEF
Performance
As reported in the abstract
Discrimination for HFpEF
| Test or model | AUC, derivation cohort (n = 414) | AUC, international multicenter validation cohort (n = 736) | AUC, unexplained dyspnea cohort (n = 228) | AUC, HF hospitalization-defined HFpEF cohort (n = 456) |
|---|---|---|---|---|
| HFpEF-ABA score | 0.839 (95% CI 0.800-0.877), P < 0.0001 | 0.813 (95% CI 0.779-0.847), P < 0.0001 | 0.840 (95% CI 0.782-0.900), P < 0.0001 | 0.929 (95% CI 0.909-0.948), P < 0.0001 |
Further findings
HF hospitalization or death (Mayo Clinic n = 790; Veteran Affairs n = 3076)
- Model-based probabilities associated with increased risk of HF hospitalization or death
Original publication
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Nat Med. Published 12 July 2024. doi:10.1038/s41591-024-03140-1
Summarised from the published abstract; every number is checked against it