Congenital heart diseaseMeta-analysis
Anatomic and Physiologic Repair of Congenitally Corrected Transposition of the Great Arteries
- Systematic review and meta-analysis
Authors' conclusion
Anatomic repair of ccTGA patients results in higher overall and reintervention-free survival compared to physiologic repair.
Study context
- Population
- Patients with congenitally corrected transposition of the great arteries (ccTGA)
- Participants
- 2,844 patients · 47 studies
- Comparison
- Anatomic repair vs physiologic repair of ccTGA
- Outcome
- Composite of:
- All-cause mortality
- Heart transplantation
- Follow-up
- During hospitalization and at 1, 5 and 10 years
Pooled result
As reported in the abstract
Mortality · 10 years
Further pooled results
| Outcome | Anatomic repair | Physiologic repair |
|---|---|---|
| Reintervention · 10 years | 24.5% (95% CI 19.2%–30.1%) | 30.3% (95% CI 23.5%–37.6%) |
Primary outcome in anatomic repair, by age at surgery <5 years and preoperative pulmonary artery banding (subgroups) · 10 years
- Significantly lower in anatomically repaired patients operated at <5 years of age and with preoperative pulmonary artery banding
- P for heterogeneity < 0.01
Original publication
Anatomic and Physiologic Repair of Congenitally Corrected Transposition of the Great Arteries. J Am Coll Cardiol. Published 20 November 2024. doi:10.1016/j.jacc.2024.07.056
Summarised from the published abstract; every number is checked against it