Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study
Study context
- Population
- Patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD) undergoing primary PCI of the culprit vessel without complete revascularizationplanned enrolment
- Participants
- 320 patients
- Primary endpoint
- Association between a composite clinical endpoint (first layer: all-cause mortality, MI, ischaemia-driven revascularization; second layer: cardiac arrest, HF, stroke, VT) and serum inflammatory markers and non-infarct-related arteries (NIRA) anatomical and physiological characteristics by CTCA, FFRCT and fat attenuation index (FAI)
- Follow-up
- 24 months
Methodological detailsrationale and design, multicentre, international, Blood sampling for inflammatory markers and coronary CT angiography (plaque burden and morphology, AI-enabled FFRCT, fat attenuation index), Statistical and machine learning methods to predict patient-, vessel- and lesion-specific risk
- Rationale and design
- Multicentre
- International
- Blood sampling for inflammatory markers and coronary CT angiography (plaque burden and morphology, AI-enabled FFRCT, fat attenuation index)
- Statistical and machine learning methods to predict patient-, vessel- and lesion-specific risk
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study. Am Heart J. Published 3 November 2025. doi:10.
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