Coronary disease & ACSCohort study
Angina with non-obstructive coronary arteries and myocardial bridge: long-term outcomes of surgical unroofing
- Prospective cohort study
- propensity-score matched
Authors' conclusion
Surgical unroofing of a symptomatic and functionally significant MB is associated with significant long-term improvement in symptoms and QoL.
Study context
- Population
- Adults with angina, non-obstructive coronary arteries and a functionally significant LAD myocardial bridge (diastolic fractional flow reserve (dFFR) and/or RFR ≤ 0.76)matched cohort 65 vs 65
- Participants
- 218 adults
- Exposure
- Surgical unroofing vs no surgery
- Unroofedn = 65
- Non-surgicaln = 65reference
- Outcome
- Long-term symptoms and QoL by Seattle Angina Questionnaire (SAQ)
- Follow-up
- Median 5 (3-9) years
Main finding
As reported in the abstract
SAQ domains · median 5 (3-9) years
- Significant and highly clinically meaningful improvement in all Seattle Angina Questionnaire (SAQ) domains (physical limitation, anginal stability, anginal frequency, treatment satisfaction, quality of life (QoL), SAQ summary score)
Observational data: associations, not effects.
Further findings
| Outcome | Unroofed | Non-surgical | P value |
|---|---|---|---|
| SAQ physical limitation improvement (matched cohort) · propensity-score matched | 27.8 | 11.4 | P = 0.004 |
| SAQ angina frequency improvement (matched cohort) · propensity-score matched | 30 | 20 | P = 0.01 |
Original publication
Angina with non-obstructive coronary arteries and myocardial bridge: long-term outcomes of surgical unroofing. Eur Heart J. Published 22 May 2026. doi:10.1093/eurheartj/ehag373
Summarised from the published abstract; every number is checked against it