Coronary disease & ACSCohort study
Angiography-Derived Fractional Flow Reserve During Percutaneous Coronary Intervention
- cohort study
- Propensity score matching (1:3)
- US Medicare beneficiary data
Authors' conclusion
Angio-FFR usage in the United States is modest but increasing. Angio-FFR guidance during angiography versus PW was associated with comparable outcomes through 2 years.
Study context
- Population
- US Medicare beneficiaries undergoing angiography with intraprocedural physiological assessment, January 1, 2019 to December 31, 2024angiograms that included intraprocedural physiological assessment, 1.00% (N=4672) used Angio-FFR · percutaneous coronary intervention (PCI) cohort, Angio-FFR 1,591 · PCI cohort, pressure wire (PW)-matched 4,773 · non-PCI cohort, Angio-FFR 2,532 · non-PCI cohort, PW-matched 7,596
- Participants
- 466,535 beneficiaries
- Exposure
- Angio-FFR guidance during angiography versus PW
- Angio-FFRn = 4,672
- Outcome
- Cumulative incidence of major adverse cardiovascular events (all-cause death, myocardial infarction, and repeat revascularization), patients with PCI
- Follow-up
- Through 2 years
Main finding
As reported in the abstract
Hazard ratio
1.01
95% CI 0.85–1.20
By group
Angio-FFR vs PW
hazard ratio 1.01 (95% CI 0.85–1.20)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Angio-FFR | PW | hazard ratio (95% CI) | |
|---|---|---|---|---|
| Major adverse cardiovascular events, non-PCI patients · through 2 years | 24.1% | 23.9% | 0.97 (0.84–1.11) | |
| 0.512Hazard ratio (log scale) |
Angio-FFR use
- Angiograms using Angio-FFR
- 1.00%
- Annual use in 2019
- 0.47%
- Annual use in 2024
- 3.85%
Secondary outcomes (individual MACE components, 30-day acute kidney injury, 30-day major bleeding) and falsification end points (hospitalization for pneumonia and hip fracture), patients with PCI
- Not significantly different
Original publication
Angiography-Derived Fractional Flow Reserve During Percutaneous Coronary Intervention. Circ Cardiovasc Interv. Published 7 March 2026. doi:10.1161/circinterventions.125.016213
Summarised from the published abstract; every number is checked against it