Heart failure & cardiomyopathies
Angiotensin Receptor-Neprilysin Inhibitor Adherence and Outcomes in Heart Failure with Reduced Ejection Fraction
Main findingResult — go to the resultHazard ratio 0.78 95% CI 0.75–0.81Authors' conclusion
In a real-world cohort with HFrEF, ARNI was superior to traditional RAS blockade in reducing the risk of all-cause mortality and hospitalization. The benefit of ARNI was pronounced among patients with high medication adherence but not among those with low medication adherence
Study context
- Population
- Patients with Heart Failure with Reduced Ejection Fraction (HFrEF), Korean National Health Insurance Service data (2017–2021)matched 1:1
- Participants
- 13,483 vs 13,483
- Exposure
- Angiotensin receptor-neprilysin inhibitor (ARNI) vs traditional renin-angiotensin system (RAS) blockade
- ARNIn = 13,483
- RAS blockaden = 13,483reference
- Outcome
- Composite of:
- All-cause mortality
- Any hospitalization
- Follow-up
- Within one year
Methodological detailsnationwide, longitudinal, propensity-score matched
- Nationwide
- Longitudinal
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio
0.78
95% CI 0.75–0.81
P < 0.001
ARNIvs RAS blockade
HR 0.78 (95% CI 0.75–0.81); P < 0.001
Observational data: associations, not effects.
Further findings
Medication adherence (PDC) over 1 year
P < 0.001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Primary outcome by adherence (PDC ≥ 80% vs PDC < 80%) (subgroup)PDC ≥ 80% | 0.75 (0.72–0.78) | P < 0.001 | |
| Primary outcome by adherence (PDC ≥ 80% vs PDC < 80%) (subgroup)PDC < 80% | 0.95 (0.85–1.05) | P = 0.313 | |
| 0.512Hazard ratio (log scale) |
- Primary outcome by adherence (proportion of days covered (PDC) ≥ 80% vs PDC < 80%) (subgroup): P for interaction <0.001
Original publication
Angiotensin Receptor-Neprilysin Inhibitor Adherence and Outcomes in Heart Failure with Reduced Ejection Fraction. ESC Heart Fail. Published 17 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →