Heart failure & cardiomyopathiesCross-sectional study
Angiotensin Receptor-Neprilysin Inhibitor Prescribing Patterns in Patients Hospitalized for Heart Failure
- Cross-sectional study
- registry-based (Get With The Guidelines-Heart Failure (GWTG-HF))
- 614 hospitals
Authors' conclusion
Results of this cross-sectional study reveal that in the 7 years after FDA drug approval of sacubitril-valsartan, rates of ARNI or ACEI, ARB, or ARNI prescription at discharge increased, and rates of ACEI or ARB prescription decreased.
Study context
- Population
- Patients hospitalized with heart failure with reduced ejection fraction (HFrEF) (EF ≤40%), GWTG-HF registry, 614 US hospitals
- Participants
- 114,333 patients
- Exposure
- Angiotensin receptor-neprilysin inhibition (ARNI), ACEi and ARB prescription at discharge across 3 time periods
- Outcome
- Rates of ARNI, ACEi and ARB prescription at discharge
Main finding
As reported in the abstract
ARNI prescription at discharge
Each group vs period 1Odds ratio (95% CI)
Period 2
3.81(3.65–3.98)
Period 3
9.15(8.79–9.52)
- ARNI prescribed at discharge, July 7, 2015, to September 30, 2015
- 1.1% (27 of 2451)
- ARNI prescribed at discharge, October 1, 2022, to December 31, 2022
- 55.4% (1957 of 3536)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| ACEi or ARB prescription at discharge — Period 2 vs Period 1 · adjusted | 0.46 (0.45–0.48) | |
| ACEi or ARB prescription at discharge — Period 3 vs Period 1 · adjusted | 0.25 (0.24–0.26) | |
| 0.20.5125Odds ratio (log scale) |
- ACEi or ARB prescription at discharge — Fell over the same period, from
- 88.3% (2612 of 2957)
- ACEi or ARB prescription at discharge — to
- 45.9% (2033 of 4434)
ACEi, ARB or ARNI prescription at discharge
- Increased over the same period, from
- 71.1% (2639 of 3713)
- to
- 84.7% (3990 of 4711)
Original publication
Angiotensin Receptor-Neprilysin Inhibitor Prescribing Patterns in Patients Hospitalized for Heart Failure. JAMA Cardiol. Published 1 March 2025. doi:10.1001/jamacardio.2024.3815
Summarised from the published abstract; every number is checked against it