Heart failure & cardiomyopathies
Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The Dilated Cardiomyopathy (DCM) Precision Medicine Study
Authors' conclusion
Approximately one-third of patients with DCM experienced flu-like illness symptoms before DCM diagnosis. We did not find evidence that a flu-like illness modified the effect of rare variants on DCM risk; however, our genome-wide association study analysis suggested that flu-like illness may modify the effect of a common variant on DCM risk.
Study context
- Population
- Patients with idiopathic dilated cardiomyopathy (DCM)patients with DCM
- Participants
- 1,164 patients
- Exposure
- Modification by antecedent flu-like illness of the effect of rare and common variants on DCM risk
- Outcome
- Symptoms of flu-like illness proximal to DCM diagnosis
Methodological detailscase-only design
- Case-only design
Main finding
As reported in the abstract
Patients reporting flu-like illness
30.2%
Observational data: associations, not effects.
Further findings
Antecedent flu-like illness by variant classification
Modification by antecedent flu-like illness of the effect of carrying any pathogenic, likely pathogenic, or variant of uncertain significance variants on DCM risk
- Interaction relative risk
- 0.9 [95% CI, 0.7-1.3]
- Not found to modify
Modification of the effect of rs2102158 (3q24) by antecedent flu-like illness (case-only genome-wide association study)
- Significant modification
- P = 2.74×10 −8
Original publication
Summarised from the published abstract; every number is checked against it