Congenital heart diseaseCohort study
Antibiotic Prophylaxis for Congenital Cardiac Catheterizations
- retrospective cohort study
- 39 pediatric centers
- Pediatric Health Information System data
Authors' conclusion
Procedure-related IE is exceedingly rare and is significantly related to procedure type. We did not observe a measurable association between early IE and ABP dosing. These findings underscore the need for standardized, evidence-based guidelines to optimize antibiotic protocols for congenital cardiac catheterization.
Study context
- Population
- Patients undergoing congenital cardiac catheterization procedures (patent ductus arteriosus (PDA) device occlusion, atrial septal defect device occlusion, ventricular septal defect device occlusion, transcatheter pulmonary valve replacement (TPVR), pulmonary or aortic balloon valvuloplasty)procedures analyzed
- Participants
- 20,580 patients
- Exposure
- Antibiotic prophylaxis (ABP) dosing strategies and procedure type in relation to early postprocedural infective endocarditis (IE)
Main finding
As reported in the abstract
Proportion of patients receiving ≥2 antibiotic doses
Observational data: associations, not effects.
Further findings
Incidence of early IE by procedure type · within 30 days
- Incidence of early IE by procedure type — varied significantly by procedure type
- P = 0.003
Early IE · within 30 days
- IE cases
- 15
- IE incidence, all procedures
- 0.07%
- share of IE cases following TPVR
- 53%
Association between ABP and early IE
- No measurable association between ABP and early IE
Original publication
Antibiotic Prophylaxis for Congenital Cardiac Catheterizations. JACC Adv. Published 9 July 2026. doi:10.1016/j.jacadv.2026.102969
Summarised from the published abstract; every number is checked against it