Antihypertensive medication prescription dispensation among pregnant women in the United States: A cohort study
Authors' conclusion
Antihypertensive prescription dispensation of both preferred and potentially harmful agents is common in pregnancy capable individuals.
Study context
- Population
- US women aged 15–54 with commercial or government insurance, free from heart disease, pregnant and filling ≥1 antihypertensive prescription from 3 months preconception to 12 months postpartum (MarketScan 2008–2014)
- Participants
- 1,058,521 pregnancies
- Outcome
- Antihypertensive dispensation patterns (continuation, initiation, discontinuation) by medication class
- Follow-up
- Preconception, first, second and third trimesters, and first year postpartum
Main finding
As reported in the abstract
- Pregnancies exposed to ≥1 antihypertensive dispensation
- 108,614 (10.3%)
- Renin-angiotensin-aldosterone system (RAAS) inhibitors dispensed, preconception (third most dispensed class)
- 26.4%
- RAAS inhibitors dispensed, second trimester
- 5.7%
- RAAS inhibitors dispensed, third trimester
- 1.7%
- Women with chronic hypertension filling preconception not dispensed an antihypertensive in first year after delivery
- 8.4%
Observational data: associations, not effects.
Original publication
Antihypertensive medication prescription dispensation among pregnant women in the United States: A cohort study. Am Heart J. Published 22 August 2024. doi:10.
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