HypertensionRandomised controlled trial
Antihypertensive Medication Timing and Cardiovascular Events and Death
- Randomised controlled trial
- multicentre
- open-label
- pragmatic
- blinded end-point assessment
Authors' conclusion
Among adults with hypertension in primary care, bedtime administration of antihypertensive medications was safe but did not reduce cardiovascular risk.
Study context
- Population
- Community-dwelling adults with hypertension taking ≥1 once-daily antihypertensive, recruited via 436 primary care clinicians in 5 Canadian provinces
- Participants
- 3,357 adults
- Comparison
- Bedtime vs morning administration of antihypertensive medications
- Bedtimen = 1,677
- Morningn = 1,680reference
- Primary endpoint
- Time to first all-cause death or hospitalization/ED visit for stroke, ACS or HF
- Follow-up
- Median 4.6 years
Primary result
As reported in the abstract
Adjusted hazard ratio
0.96
95% CI 0.77–1.19
P = 0.70
By group
Bedtime vs Morning
adjusted HR 0.96 (95% CI 0.77–1.19); P = 0.70
Further findings
Individual components of the primary outcome, all-cause hospitalizations/ED visits
- Did not differ between groups
Safety
Safety outcomes: falls or fractures, new glaucoma diagnoses, 18-month cognitive decline
- No difference between groups
Original publication
Antihypertensive Medication Timing and Cardiovascular Events and Death. JAMA. Published 17 June 2025. doi:10.1001/jama.2025.4390
Summarised from the published abstract; every number is checked against it