Aortic & peripheral vascular diseaseCross-sectional study
Aortic Aneurysm Risk and the Somatic JAK2 V617F Mutation: Insights From a Multicenter, Population-Based Cardiovascular Screening Study
- Cross-sectional study
- substudy of the DANCAVAS I and II trials
- multicenter
- population-based screening
Authors' conclusion
In a study population of primarily men 60 to 74 years of age, the somatic JAK2V617F sequence variation was strongly and independently associated with ascending aortic aneurysms, presenting a positive correlation between aneurysm size and JAK2V617F VAF. No convincing associations were observed for descending or abdominal aneurysms.
Study context
- Population
- Individuals from Danish CV screening (DANCAVAS) with screening-detected aortic aneurysms, random aneurysm-free male controls and all women from the pilot; primarily men 60 to 74 years90.9% men
- Participants
- 8,056 individuals
- Exposure
- JAK2V617F variant allele frequency (VAF) <1% and ≥1% vs JAK2V617F-negative
- JAK2V617F-negativen = 7,486reference
- VAF <1%n = 491
- VAF ≥1%n = 79
- Outcome
- Association of JAK2V617F VAF with ascending, descending and abdominal aortic aneurysms
Main finding
As reported in the abstract
Ascending aortic aneurysm
Each group vs JAK2V617F-negativeAdjusted odds ratio (95% CI)P value
VAF <1%
1.4(1.01–2.0)
P = 0.045VAF ≥1%
2.7(1.5–5.1)
P = 0.002- Ascending aneurysm prevalence across groups
- P < 0.001
- Risk of ascending aneurysm per doubling in VAF: increased by 11%
- Padjusted=0.013
Observational data: associations, not effects.
Further findings
Median
| Outcome | Ascending aneurysm | Controls |
|---|---|---|
| Median VAF among JAK2V617F-positive: ascending aneurysm vs controls | 9.5% (IQR 3.0–40.0) | 4.4% (IQR 1.8–20.0) |
- Median VAF among JAK2V617F-positive: ascending aneurysm vs controls: P=0.021
JAK2V617F prevalence (overall)
- Overall prevalence
- 7.1%
Descending and abdominal aneurysms
- No significant differences across groups; not significantly associated after adjustment
Ascending aortic diameter vs VAF
- Spearman ρ
- 0.10
- P
- P = 0.026
- No significant correlations for descending or abdominal diameters
Original publication
Aortic Aneurysm Risk and the Somatic JAK2 V617F Mutation: Insights From a Multicenter, Population-Based Cardiovascular Screening Study. Circulation. Published 4 June 2025. doi:10.1161/circulationaha.125.074002
Summarised from the published abstract; every number is checked against it