Heart failure & cardiomyopathies
Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg?
Authors' conclusion
Combination of AS and TTR-CA may occur in elderly patients particularly those with a low-flow low-gradient AS pattern and carries bad prognosis.
Study context
- Population
- Patients with severe or moderate aortic stenosis (AS) and transthyretin cardiac amyloidosis (TTR-CA) hospitalised in 6 French cardiology centres over 6 years
- Participants
- 16 patients
- Outcome
- Characteristics of patients with concomitant AS and TTR-CA
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Age, mean ± SD
- 79 ± 6 years
- Men
- 81%
- NYHA III-IV
- Sixty per cent
- Carpal tunnel syndrome
- 31%
- AF
- 56%
- NT-proBNP, median (Q1;Q4)
- 4382 (2425;4730) pg/mL
- Elevated cardiac troponin
- 91%
- Severe AS
- Eighty-eight per cent (n = 14/16)
- Low-gradient AS among severe AS
- 86% (n = 12)
- Interventricular septum thickness, mean ± SD
- 18 ± 4 mm
- LVEF, mean
- 50 ± 13%
- Global LS, mean
- −7 ± 4%
- TTR-CA histologically proven (rest by biphosphonate scintigraphy)
- 38%
- Wild-type TTR-CA
- Eighty-one per cent (n = 13)
- Mutated Val122I
- one
- No genetic test
- 19% (n = 3)
- Surgical valve replacement
- 63%
- Transcatheter valve replacement
- 13%
- Mortality over whole follow-up
- 44% (n = 7)
Observational data: associations, not effects.
Original publication
Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg? Eur Heart J. Published 22 February 2016. doi:10.
Summarised from the published abstract; every number is checked against it