Heart failure & cardiomyopathiesDiagnostic or prognostic study
Area-weighted unipolar voltage to predict heart failure outcomes in patients with ischaemic cardiomyopathy and ventricular tachycardia
- Cohort study with derivation and validation cohorts
- consecutive patients
Authors' conclusion
The newly proposed parameter awUV, easily available from routine voltage mapping, may be useful at identifying ICM patients at high risk for HFO.
Study context
- Population
- Patients with ischaemic cardiomyopathy referred for catheter ablation of ventricular tachycardia (VT)
- Participants
- 90 vs 60
- Comparison
- Low vs high area-weighted unipolar voltage (awUV)
- Derivationn = 90
- Validationn = 60
- Outcome
- Heart failure (HF)-related outcomes (HF death/LV assist device/heart transplant)
Performance
As reported in the abstract
awUV in patients with vs without HFO (derivation cohort) · median follow-up 45 months [IQR (34-83)]
HFO
4.51
IQR 3.69–5.31
No HFO
7.03
IQR 6.08–9.2
P < 0.001
- Reduced awUV (cut-off 5.58, ROC-determined) a strong predictor of HFO: 3-year HFO survival
- 97% vs. 57%
Further findings
Events in derivation cohort · median follow-up 45 months
- Died
- 36 (43%)
- HFO
- 23 (26%)
Validation of awUV cut-off: 2-year HFO-free survival
- Cut-off confirmed in validation cohort
- 96% vs. 60%
Original publication
Area-weighted unipolar voltage to predict heart failure outcomes in patients with ischaemic cardiomyopathy and ventricular tachycardia. Europace. Published 3 February 2024. doi:10.1093/europace/euad346
Summarised from the published abstract; every number is checked against it