Arrhythmias & electrophysiology
Arrhythmia and Survival Outcomes Among Black Patients and White Patients With a Primary Prevention Defibrillator
Authors' conclusion
Among patients with NICM with an ICD for primary prevention, Black patients compared with White patients had a high risk and burden of VTA, ATA, and ICD therapies with a lower survival rate. Nevertheless, the overall benefit of the ICD was maintained and was similar to that of White patients.
Study context
- Population
- US ICD recipients with ischemic or nonischemic cardiomyopathy enrolled in primary prevention ICD trials
- Participants
- 3,895 recipients
- Comparison
- Black vs White patients with a primary prevention ICD
- Outcome
- VTA, ATA, ICD therapies, VTA burden, death and predicted ICD benefit
Methodological detailsblinded event adjudication, multivariable analysis
- Blinded event adjudication
- Multivariable analysis
Pooled result
As reported in the abstract
Black
- Ventricular tachyarrhythmia (VTA) ≥170 bpm
- 32%
- VTA ≥200 bpm
- 22%
- Atrial tachyarrhythmia (ATA)
- 25%
- Appropriate therapy
- 30%
- Inappropriate therapy
- 25%
White
- VTA ≥170 bpm
- 20%
- VTA ≥200 bpm
- 14%
- ATA
- 12%
- Appropriate therapy
- 20%
- Inappropriate therapy
- 11%
Ventricular tachyarrhythmia (VTA) ≥170 bpm
Black32%
White20%
VTA ≥200 bpm
Black22%
White14%
Atrial tachyarrhythmia (ATA)
Black25%
White12%
Appropriate therapy
Black30%
White20%
Inappropriate therapy
Black25%
White11%
- VTA ≥170 bpm, multivariable
- HR 1.71; P ≤ 0.01
- VTA ≥200 bpm, multivariable
- HR 1.58; P ≤ 0.01
- ATA, multivariable
- HR 1.87; P ≤ 0.01
- Appropriate therapy, multivariable
- HR 1.62; P ≤ 0.01
- Inappropriate therapy, multivariable
- HR 1.86; P ≤ 0.01
Further pooled results
| Outcome | HR | P value |
|---|---|---|
| Burden of tachyarrhythmias or therapies in NICM (Andersen-Gill)Black vs White · VTA | 1.84 | P < 0.001 |
| Burden of tachyarrhythmias or therapies in NICM (Andersen-Gill)Black vs White · appropriate therapy | 1.84 | P < 0.001 |
| Death in NICM | 1.92 | P = 0.014 |
Tachyarrhythmia, ICD therapy or death in ischemic cardiomyopathy
- Similar between Black and White patients
Benefit of ICD implantation
- Significant and similar benefit in Black and White patients
Original publication
Arrhythmia and Survival Outcomes Among Black Patients and White Patients With a Primary Prevention Defibrillator. Circulation. Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →