Cohort study
Arrhythmias in congenitally corrected transposition of the great arteries: an international study
- Retrospective cohort study
- multicentre
- international
- 29 tertiary hospitals, 6 countries
Authors' conclusion
The arrhythmia burden in patients with ccTGA is substantial, with a high incidence of AA, VA, and CAVB.
Study context
- Population
- Patients with congenitally corrected transposition of the great arteries (ccTGA), 1990–2018median follow-up 9.0 years
- Participants
- 1,131 patients
- Outcome
- Combined outcome of AA, VA or CAVB, and its individual components (incidence)
Main finding
As reported in the abstract
Cumulative rate of combined AA, VA or CAVB
- Cumulative rate at 10 years
- 44.5%
- Cumulative rate at 15 years
- 51.0%
- Cumulative rate at 20 years
- 58.8%
- Atrial arrhythmia (AA) incidence (per 100 person-years)
- 2.1
- Ventricular arrhythmia (VA) incidence (per 100 person-years)
- 1.4
- Complete atrioventricular block (CAVB) incidence (per 100 person-years)
- 2.0
Observational data: associations, not effects.
Further findings
Factors associated with arrhythmias (multivariable Cox)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Surgery/intervention · AA | 3.01 (1.90–4.78) | P < 0.001 | |
| Surgery/intervention · VA | 1.73 (0.98–3.05) | P = 0.003 | |
| Surgery/intervention · CAVB | 3.65 (2.20–6.05) | P < 0.001 | |
| Left bundle branch block · VA | 4.03 (1.59–10.23) | P = 0.003 | |
| Right bundle branch block · CAVB | 3.71 (1.81–7.63) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Arrhythmias in congenitally corrected transposition of the great arteries: an international study. Eur Heart J. Published 18 July 2025. doi:10.1093/eurheartj/ehaf466
Summarised from the published abstract; every number is checked against it