Arrhythmias & electrophysiology
Arrhythmic manifestations and outcomes of definite and probable cardiac sarcoidosis
Authors' conclusion
Patients with definite and probable CS had similarly high risks of first sustained VT/VF/sudden cardiac death and all-cause mortality, though patients with definite CS had a higher overall arrhythmia burden.
Study context
- Population
- Patients diagnosed with cardiac sarcoidosis, single-centre North American cohort, 2000–2022 (median age 56 years; 39% female)
- Participants
- 388 patients
- Exposure
- Definite vs probable cardiac sarcoidosis
- Definite CSn = 58
- Probable CSn = 330reference
- Outcome
- Survival to first VT/VF event or SCD
- Follow-up
- Median 3.1 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = 0.55
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Predictor of primary outcome (multivariable): myocardium-to-blood-pool 18F-FDG SUVmax ratio, per 1 unit increase · per 1 unit increase; only factor associated | 1.09 (1.03–1.15) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
Device-treated VT/VF burden
Progression to heart transplant/LV assist device
- Higher rate in definite CS
All-cause mortality
- No difference between definite and probable CS
Original publication
Arrhythmic manifestations and outcomes of definite and probable cardiac sarcoidosis. Heart Rhythm. Published 6 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it