Heart failure & cardiomyopathiesCohort study
Arrhythmic Risk Stratification According to Late Gadolinium Enhancement (LGE) Corridors and Genetics in Nonischemic Dilated Cardiomyopathy
- Multicentre cohort study
- consecutive patients
- 22 European centres
- competing-risk analysis
Authors' conclusion
LGE corridors and HRGs provide additive value for arrhythmic risk stratification in patients with nonischemic dilated cardiomyopathy.
Study context
- Population
- Patients with nonischemic dilated cardiomyopathy who had undergone genetic testing and CMR, 22 European centres
- Participants
- 925 patients
- Exposure
- LGE corridors and high-risk genotypes as predictors of major ventricular arrhythmic events
- LGE corridorsn = 160
- HRGn = 119
- Outcome
- Major ventricular arrhythmic events (MVA)
- Follow-up
- Median 5.4 years
Main finding
As reported in the abstract
MVA · median follow-up 5.4 years (IQR 3.3-7.7)
Subdistribution hazard ratio (95% CI)P value
Number of LGE corridors
1.25(1.11–1.42)
P < 0.001HRG
2.28(1.32–3.96)
P = 0.003- Patients with an MVA
- 95 (10.3%)
Observational data: associations, not effects.
Further findings
| Outcome | Stepwise algorithm | LVEF ≤35% | P value |
|---|---|---|---|
| Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification · 5 years | P = 0.001 | ||
| time-dependent AUC | 0.72 (95% CI, 0.65-0.78) | 0.57 (95% CI, 0.51-0.64) |
- Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification — Progressive increase in arrhythmic risk across categories
- Gray test P<0.001
Prediction of MVA: stepwise algorithm (LGE, ≥4 LGE corridors, HRG) vs LVEF ≤35%-based guideline classification · 5 years
- Optimal cutoff of ≥4 LGE corridors predicted MVA
Original publication
Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy. Circulation. Published 8 September 2026. doi:10.1161/circulationaha.126.080608
Summarised from the published abstract; every number is checked against it