Cardiometabolic & kidneyCohort study
Arterial stiffness mediates insulin resistance-related risk of atherosclerotic cardiovascular disease: a real-life, prospective cohort study
- Prospective cohort study
- mediation analysis
Authors' conclusion
The association between IR indices and ASCVD was found to be partly mediated by baPWV, indicating a pathway connecting IR to ASCVD outcomes
Study context
- Population
- Kailuan Study Arterial Stiffness Subcohort participants free of atherosclerotic cardiovascular disease (ASCVD) at baseline2,073 ASCVD cases
- Participants
- 59,777 participants
- Exposure
- Insulin resistance and ASCVD, mediated by arterial stiffness
- Outcome
- Proportion of the insulin resistance (IR)–ASCVD association mediated by baPWV
- Follow-up
- Median 5.97 years
Main finding
ASCVD
Hazard ratio
1.23
95% CI 1.17–1.30
TyG index
HR 1.23 (95% CI 1.17–1.30)
As reported in the abstract
- Proportion of TyG–ASCVD association mediated by brachial-ankle pulse wave velocity (baPWV)
- 11.1%
Observational data: associations, not effects.
Further findings
CHD and ischaemic stroke
- Proportion of TyG–CHD association mediated by baPWV
- 6.58%
- Proportion of TyG–ischaemic stroke association mediated by baPWV
- 14.0%
- 478 CHD and 1636 ischaemic stroke cases
Metabolic score for insulin resistance (METS-IR)
- Similar patterns observed for METS-IR
Original publication
Arterial stiffness mediates insulin resistance-related risk of atherosclerotic cardiovascular disease: a real-life, prospective cohort study. Eur J Prev Cardiol. Published 23 January 2025. doi:10.1093/eurjpc/zwaf030
Summarised from the published abstract; every number is checked against it