Arrhythmias & electrophysiologyCohort study
Arterial Thromboembolism in Patients With Atrial Fibrillation and CHA 2 DS 2 -VASc Score 1: A Nationwide Study
- Retrospective cohort study
- nationwide
- Danish registries
Authors' conclusion
For patients with atrial fibrillation, all subgroups of CHA2DS2-VASc 1 were associated with lower incidence of arterial thromboembolism compared with age ≥75 years without other risk factors (ie, CHA2DS2-VASc 2) and a higher incidence compared with CHA2DS2-VASc 0. No statistically significant difference was identified between the subgroups of CHA2DS2-VASc 1.
Study context
- Population
- Patients with AF without OAC, Danish nationwide registries, 2000–2021; female sex not counted as a risk factorCHA2DS2-VASc 1 n = 22,915
- Participants
- 26,701 / 1,483 / 9,066 / 843 / 770 / 10,753 / 14,525
- Exposure
- CHA2DS2-VASc 1 subgroups vs CHA2DS2-VASc 0 and CHA2DS2-VASc 2
- CHA2DS2-VASc 0n = 26,701reference
- Heart failuren = 1,483
- Hypertensionn = 9,066
- Diabetesn = 843
- Vascular diseasen = 770
- Age 65–74 yearsn = 10,753
- Age ≥75 yearsn = 14,525
- Outcome
- Arterial thromboembolism (ischemic stroke, embolism of extremity or TIA)
- Follow-up
- Median 1 year of observation
Main finding
As reported in the abstract
Cumulative incidence of arterial thromboembolism · median 1 year
- No statistically significant difference among subgroups of CHA2DS2-VASc 1
- P = 0.15
Observational data: associations, not effects.
Original publication
Arterial Thromboembolism in Patients With Atrial Fibrillation and CHA 2 DS 2 -VASc Score 1: A Nationwide Study. Circulation. Published 28 December 2023. doi:10.1161/circulationaha.123.066477
Summarised from the published abstract; every number is checked against it