Heart failure & cardiomyopathies
Arterio-venous gradient of active interleukin-18 is associated with diastolic dysfunction: a cross-sectional study
Authors' conclusion
The aIL-18 A/V ratio correlated with markers of diastolic dysfunction, particularly in patients with increased filling pressure. These exploratory findings indicate an association between local IL-18 gradients and diastolic dysfunction, warranting further investigation.
Study context
- Population
- Patients undergoing diagnostic cardiac catheterizationpatients enrolled
- Participants
- 87 patients
- Exposure
- Associations between arterio-venous (A/V) cytokine gradients and diastolic dysfunction
- Outcome
- Cohort characteristics: septal e′ and ejection fraction
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
Septal e′
5.3 ± 2.0 cm/s
Ejection fraction
57.4 ±11.8%
Observational data: associations, not effects.
Further findings
Correlation of aIL-18 A/V ratio with average E/e′, tricuspid regurgitation pressure gradient and HFA-PEFF score
- Average E/e′
- r = 0.31, P < .01
- Tricuspid regurgitation pressure gradient
- r = 0.29, P = .015
- HFA-PEFF score
- r = 0.23, P = .034
aIL-18 A/V ratio and E/e′ correlation by subgroup
- More pronounced in non-diabetic patients and in those with elevated left ventricle (LV) filling pressure (average E/e′ ≥ 15)
Interleukin-6
- Correlated with albuminuria and pulmonary function; no synergistic interaction with aIL-18
In vitro fibrotic responses in human cardiac fibroblasts
- aIL-18 stimulated fibroblast proliferation and collagen synthesis
Original publication
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