Coronary disease & ACSCohort study
Assessing Coronary Calcium Thresholds on Attenuation-Correction Computed Tomography (CT) With Myocardial Perfusion Imaging Equating to Secondary Prevention
- retrospective study
- single center
Authors' conclusion
Patients without prior ASCVD but with severe CAC (score ≥7) on CTAC demonstrated a risk for cardiovascular events and mortality comparable to those with known ASCVD, highlighting the need for more aggressive management in this high-risk primary prevention group.
Study context
- Population
- Patients who underwent nuclear myocardial perfusion imaging with CTAC (single photon emission computed tomography/CT or positron emission tomography/CT)patients who underwent nuclear myocardial perfusion imaging with CTAC · without prior atherosclerotic cardiovascular disease (ASCVD) 13,852 · with ASCVD 4,049
- Participants
- 17,901 patients
- Exposure
- patients with severe calcification vs ASCVD patients
- ASCVDn = 4,049
- Outcome
- composite of:
- Death
- MI
- Late revascularization
- Follow-up
- Median 25 (Q1-Q3: 10-43) months
Main finding
As reported in the abstract
patients experienced major adverse cardiac events (MACE)
2,006 patients (11%)
Observational data: associations, not effects.
Further findings
CAC distribution among patients without prior ASCVD
Original publication
Assessing Coronary Calcium Thresholds on Attenuation-Correction CT With Myocardial Perfusion Imaging Equating to Secondary Prevention. JACC Adv. Published 17 April 2026. doi:10.1016/j.jacadv.2026.102732
Summarised from the published abstract; every number is checked against it