Coronary disease & ACSSecondary analysis
Assessing the Prognostic Value of Serial Seattle Angina Questionnaire Scores in Chronic Coronary Disease
- Secondary analysis of a randomized controlled trial (ISCHEMIA)
- global, multicenter
- stratified by treatment strategy
- Cox proportional hazards models adjusting for 17 clinical covariates
Authors' conclusion
In patients with chronic coronary disease, the most recent SAQ-SS is the strongest health status predictor of future cardiovascular events. Serial SAQ-SS assessments provide a practical, dynamic, and patient-centered approach for updating prognosis in chronic coronary disease management.
Study context
- Population
- Patients with chronic coronary disease in the ISCHEMIA trial with serial Seattle Angina Questionnaire Summary Score (SAQ-SS) assessments (3-month score as prior, 6-month score as current)participants included in this analysis · conservative management 1,965 · invasive management 1,440
- Participants
- 3,405 patients
- Comparison
- Association of the prior score, the current score, and the change in scores with ISCHEMIA's primary composite end point, stratified by treatment strategy
- conservative managementn = 1,965
- invasive managementn = 1,440
- Primary endpoint
- ISCHEMIA's primary composite end point:
- Cardiovascular death
- Myocardial infarction
- Hospitalization for unstable angina
- Heart failure
- Resuscitated cardiac arrest
- Follow-up
- Median 3.2 years
Primary result
As reported in the abstract
Hazard ratio (95% CI)
each 5-point increase in the current SAQ-SS (conservative cohort)7% lower risk of the primary end point
0.93(0.90–0.96)
each 5-point increase in the current SAQ-SS (invasive cohort)9% lower risk
0.91(0.86–0.96)
Each 5-point increase in the current SAQ-SS, as printed
Original publication
Assessing the Prognostic Value of Serial Seattle Angina Questionnaire Scores in Chronic Coronary Disease. Circ Popul Health Outcomes. Published 5 August 2026. doi:10.1161/circoutcomes.125.013063
Summarised from the published abstract; every number is checked against it