Cardio-oncology & otherCohort study
Assisted Reproductive Technology for Adults With Congenital and Acquired Heart Disease
- Retrospective analysis of the Standardized Outcomes in Reproductive Cardiovascular Care cohort
- matched 2:1
- age-matched controls
Authors' conclusion
In individuals with CVD, pregnancy outcomes following ART were comparable to those with spontaneous conception, supporting the safety of ART in this population.
Study context
- Population
- Individuals with congenital or acquired cardiovascular disease (CVD) who achieved pregnancy, followed for 1-year postpartum
- Participants
- 100 vs 200
- Exposure
- Assisted reproductive technology (ART) vs Spontaneous conception
- ARTn = 100
- Spontaneous conceptionn = 200
Main finding
As reported in the abstract
P = 1.0
Observational data: associations, not effects.
Further findings
Sustained arrhythmia · no significant difference
P = 0.34
Hypertensive disorders of pregnancy · no difference
P = 0.20
Preterm birth · no difference
P = 0.85
Need for neonatal intensive unit admission · no difference
P = 0.13
Birthweight · no difference
P = 0.40
Short-term efficacy of ART at the primary center (exploratory)
- subjects undergoing in vitro fertilization cycles
- 41
- in vitro fertilization cycles
- 57
- median oocytes per retrieval
- 15
- embryo transfers
- 85
- implantation rate
- 56.2%
- live birth rate
- 57.7%
- exploratory analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it