Association Between a Novel Adult Congenital Heart Disease-Specific Patient-Reported Health Status Metric and Objective Clinical Status
Authors' conclusion
A lower ACHD PRO V.1 summary score is associated with a history of unplanned cardiac admission. In addition, the ACHD PRO V.1 domains show good content validity by comparison with relevant clinical conditions and gold standard PROs.
Study context
- Population
- Adults with congenital heart disease enrolled in APPROACH IS-II (English-speaking subgroup), February 10, 2019 – December 14, 2022
- Participants
- 333 adults
- Outcome
- Association between ACHD PRO V.1 summary score (patient-perceived health status) and hospital admission within the preceding 5 years
Methodological detailsinternational cohort, English-speaking subgroup
- International cohort
- English-speaking subgroup
Main finding
As reported in the abstract
Worse patient-perceived health status associated with unplanned hospital admission (adjusted β)
−5.7
95% CI −9.9 to −1.6P=0.007
Observational data: associations, not effects.
Further findings
Adult congenital heart disease (ACHD) PRO V.1 domains vs domain-relevant clinical variables
- Strong association between ACHD PRO V.1 domains and relevant clinical variables
- Univariate analysis
Correlation of QOL and anxiety/depression domains with gold standard patient-reported outcomes (PROs)
- Linear Analog Scale Quality of Life
- r=0.467, P<0.001
- Patient Health Questionnaire-8
- r=−0.581, P<0.001
- Generalized Anxiety Disorder-7
- r=−0.540, P<0.001
- Moderate correlation
Original publication
Association Between a Novel Adult Congenital Heart Disease-Specific Patient-Reported Health Status Metric and Objective Clinical Status. Circ Heart Fail. Published 9 December 2025. doi:10.
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