Association between adverse birth outcomes and long-term risk of premature cardiovascular disease and mortality in a contemporary population-based cohort of 502,383 pregnant women
Corrected 23 Oct 2026: The values shown beside the hazard ratios were the share of mothers with each birth outcome, not the outcome's rate; removed.
Authors' conclusion
Adverse birth outcomes of stillbirth and preterm birth, and to a lesser degree term births that result in LBW or HBW, are markers of increased risk of premature CVD and death in the mother.
Study context
- Population
- Pregnant women in Alberta, Canada, 2005–2023
- Participants
- 502,383 women
- Exposure
- Adverse birth outcomes vs normal birth weight
- Outcome
- Composite of:
- CVD-related hospitalization
- CVD-related ED visit
- Death
- Follow-up
- Median 3612 days (∼10 years)
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Each group vs NBWAdjusted hazard ratio (95% CI)
Stillbirth
1.63(1.33–1.99)
PTB
1.45(1.36–1.55)
LBW
1.22(1.06–1.41)
HBW
1.13(1.03–1.23)
Observational data: associations, not effects.
Further findings
Other predictors of CVD or death
- Pre-existing DM, aHR
- 1.61 (1.47, 1.76) (95% CI)
- Gestational hypertension, aHR
- 1.47 (1.38, 1.57) (95% CI)
- Pre-existing hypertension, aHR
- 3.28 (2.66, 4.04) (95% CI)
Original publication
Association between adverse birth outcomes and long-term risk of premature cardiovascular disease and mortality in a contemporary population-based cohort of 502,383 pregnant women. Am Heart J. Published 16 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →