Coronary disease & ACSSecondary analysis
Association Between Age and Percutaneous Coronary Intervention (PCI) Effectiveness in Stable CAD
- Post hoc analysis of the ORBITA-2 randomised trial
- placebo-controlled
- bayesian analysis
Authors' conclusion
PCI was effective across all ages in reducing angina frequency. Notably, there was limited improvement in treadmill exercise time in the elderly, challenging its role as a primary endpoint in many antianginal trials.
Study context
- Population
- Patients with stable angina and single- or multivessel CAD without background antianginal medication (ORBITA-2)all ORBITA-2 patients
- Comparison
- PCI vs placebo, by age
- Primary endpoint
- Interaction between age and PCI efficacy on ORBITA-2 primary and secondary endpoints
Primary result
As reported in the abstract
PCI vs PlaceboOdds ratio (95% CrI)
symptom relief, older patients; Pr > 0.99
2.03(1.67–2.45)
symptom relief, younger patients; Pr > 0.99
1.70(1.38–2.15)
Difference, s
- treadmill exercise time, 50-year-old; Pr > 0.99
- +125 (95% CrI 35.8–215.0)
- treadmill exercise time, 70-year-old; Pr = 0.92
- +31.9 (95% CrI −12.6 to 78.3)
Original publication
Association Between Age and PCI Effectiveness in Stable CAD. J Am Coll Cardiol. Published 27 January 2026. doi:10.1016/j.jacc.2025.10.086
Summarised from the published abstract; every number is checked against it