Aortic & peripheral vascular diseaseMeta-analysis
Association between alcohol consumption and peripheral artery disease: two de novo prospective cohorts and a systematic review with meta-analysis
- Prospective cohort studies and systematic review with meta-analysis of observational studies
- two de novo cohorts
- nonlinear meta-analysis
- sensitivity meta-analysis
Authors' conclusion
Alcohol intake ≤2 drinks/week was associated with a reduced risk of PAD, and the risk of PAD became pronounced with intake ≥10 drinkers/week.
Study context
- Population
- Swedish and British adults (two cohorts) and previously published observational studiescohorts of 70,116 and 405,406
- Comparison
- Light, moderate and high-to-heavy alcohol drinking vs non- or never-drinking
- Outcome
- Incident PAD
Pooled result
As reported in the abstract
PAD risk (meta-analysis)
Each group vs Non- or never-drinkersRelative risk (95% CI)
Light
0.83(0.77–0.89)
Moderate
0.81(0.74–0.90)
High-to-heavy
0.94(0.83–1.07)
Further pooled results
Peripheral artery disease (PAD) risk in the Swedish and British cohorts
- U-shaped association between alcohol consumption and incident PAD risk
Nonlinear dose-response meta-analysis
- Possibly U-shaped association
- P nonlinearity <0.001
- Lowest PAD risk at 2 drinks/week; pronounced at ≥10 drinks/week
Sensitivity meta-analysis incl. cohort and other observational studies
- All associations persisted
Original publication
Association between alcohol consumption and peripheral artery disease: two de novo prospective cohorts and a systematic review with meta-analysis. Eur J Prev Cardiol. Published 16 April 2024. doi:10.1093/eurjpc/zwae142
Summarised from the published abstract; every number is checked against it