Coronary disease & ACSCohort study
Association Between Angiography-Derived Murray Law–Based Quantitative Flow Ratio and 1-Year Coronary Artery Bypass Graft Patency
- Retrospective cohort study
Authors' conclusion
The functional significance of coronary artery stenosis of target vessels, as measured by μFR, is associated with 1-year graft patency after off-pump CABG with an optimal cutoff value of 0.77
Study context
- Population
- Patients undergoing isolated off-pump coronary artery bypass grafting (CABG) for 3-vessel disease with 1-year graft evaluation2,324 distal anastomoses
- Participants
- 809 patients
- Exposure
- Preoperative μFR of target vessels and 1-year graft patency after CABG
- Outcome
- Graft patency
- Follow-up
- 1 year
Main finding
1-year graft patency by μFR
Odds ratio
0.847
95% CI 0.731–0.982
P = 0.03
μFR
OR 0.847 (95% CI 0.731–0.982); P = 0.03
As reported in the abstract
- 1-year graft occlusion rate
- 5.1% (118 of 2,324 anastomoses; 95% CI: 4.2-6.1)
- Optimal μFR cutoff (lowest P value; strongest discrimination 0.75–0.78)
- 0.77
Observational data: associations, not effects.
Further findings
Early graft patency by μFR
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| μFR · multivariable analysis | 0.941 (0.746–1.186) | P = 0.60 | |
| 0.512Odds ratio (log scale) |
- Early graft patency by μFR — Early graft occlusion rate
- 0.8% (19 of 2,324 anastomoses; 95% CI: 0.5-1.3)
Original publication
Association Between Angiography-Derived Murray Law–Based Quantitative Flow Ratio and 1-Year Coronary Artery Bypass Graft Patency. JACC Cardiovasc Interv. Published 13 October 2025. doi:10.1016/j.jcin.2025.08.027
Summarised from the published abstract; every number is checked against it