Valvular & structural heart diseaseCohort study
Association Between Aortic Wall Thrombus and Thromboembolic Events After Transfemoral Transcatheter Aortic Valve Replacement
- Prospective cohort study
- consecutive patients
Authors' conclusion
The presence of severe AWT on preprocedural multidetector computed tomography is strongly associated with thromboembolic complications including stroke and mortality after TF TAVR.
Study context
- Population
- Patients undergoing transfemoral (TF) transcatheter aortic valve replacement (TAVR) for severe AS, January 2011 to April 2022
- Participants
- 641 patients
- Exposure
- Severe aortic wall thrombus (AWT) vs no severe AWT
- Severe AWTn = 73
- Outcome
- Composite of procedural thromboembolic events (ischemic stroke, blue toe syndrome, bowel ischemia or other solid organ infarction)
Main finding
As reported in the abstract
Odds ratio
8.48
95% CI 3.36–21.40
P < 0.001
Severe AWT vs No severe AWT
OR 8.48 (95% CI 3.36–21.40); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Stroke | 5.66 (2.00–15.30) | P = 0.002 | |
| Procedural death | 4.66 (1.80–11.30) | P = 0.002 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Association Between Aortic Wall Thrombus and Thromboembolic Events After Transfemoral Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 22 July 2024. doi:10.1016/j.jcin.2024.05.033
Summarised from the published abstract; every number is checked against it