Arrhythmias & electrophysiologyResearch article
Association between baseline haptoglobin and early renal injury after pulsed-field ablation
- Patients prospectively enrolled
Authors' conclusion
Lower baseline haptoglobin was associated with early renal injury after PFA, suggesting a role in susceptibility to hemolysis-related renal stress. Targeted supplementation appears feasible but requires validation.
Study context
- Population
- Patients undergoing pulsed-field ablation (PFA)patients undergoing PFA prospectively enrolled · analytical cohort (without haptoglobin supplementation) 481 · exploratory supplementation cohort (intravenous haptoglobin) 12
- Participants
- 493 patients
- Comparison
- Baseline haptoglobin levels and early renal injury after PFA
- analytical cohortn = 481
- exploratory supplementation cohortn = 12
- Outcome
- Early renal injury (increase in creatinine of ≥0.2 mg/dL within 24 hours), primary exploratory endpoint
- Follow-up
- Within 24 hours
Main finding
As reported in the abstract
Odds ratio
0.985
P = 0.025
Events by group
analytical cohort
3.3%
16 of 481
Secondary outcomes
| Outcome | analytical cohort | exploratory supplementation cohort |
|---|---|---|
| Kidney Disease: Improving Global Outcomes-defined acute kidney injury (secondary endpoint) | 1.2% | Not reported in the abstract |
Correlation of haptoglobin decline with PFA deliveries, among patients with baseline haptoglobin of ≥80 mg/dL
- r
- 0.36
- P
- P < 0.001
Hemoglobinuria and renal function in the exploratory supplementation cohort
- Hemoglobinuria resolved rapidly whereas renal function remained stable
Original publication
Association between baseline haptoglobin and early renal injury after pulsed-field ablation. Heart Rhythm. Published 25 May 2026. doi:10.1016/j.hrthm.2026.05.026
Summarised from the published abstract; every number is checked against it