Heart failure & cardiomyopathies
Association Between Biomarkers of Zinc and Copper Status and Heart Failure: A Meta-Analysis
Authors' conclusion
This meta-analysis demonstrates that patients with HF have lower serum zinc and higher copper concentrations compared with healthy subjects.
Study context
- Population
- Patients with heart failure (HF) compared with healthy controls
- Comparison
- HF vs healthy controls
- Outcome
- Serum zinc and copper levels
Methodological detailsrandom effects model, meta-regression
- Random effects model
- Meta-regression
Pooled result
As reported in the abstract
HF vs HCsSMD (95% CI)
Serum zinc; I2 = 61.9%, P for Q test = 0.002
−0.77(−1.01 to −0.54)
Serum copper; I2 = 93.8%, P for Q test < 0.001
0.66(0.09–1.23)
Further pooled results
Sources of heterogeneity (meta-regression)
- Publication year, age and gender not responsible for heterogeneity
Original publication
Association Between Biomarkers of Zinc and Copper Status and Heart Failure: A Meta-Analysis. ESC Heart Fail. Published 1 May 2024. doi:10.
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