Coronary disease & ACS

Association Between Cancer Treatment History and Coronary Inflammation

JACC AdvPublished Cross-sectional study

Main finding · Prevalence of high-FAIResult — go to the resultRelative risk 1.56 95% CI 1.23–1.97

Authors' conclusion

In this population, a cancer history, especially in patients with current or recent treatment history, was significantly associated with elevated coronary inflammation.

Study context

Population
Patients undergoing coronary CT angiography, 2017–2018
Participants
1,141 patients
Exposure
Cancer history vs no cancer history
  • Cancern = 188
  • Noncancern = 953reference
Outcome
High-FAI (perivascular fat attenuation index in the right coronary artery above the 75th percentile)

Main finding

Prevalence of high-FAI

Relative risk

1.56

95% CI 1.23–1.97

Cancervs Noncancer
RR 1.56 (95% CI 1.23–1.97)

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeRR (95% CI)
High-FAI by time after cancer treatment (subgroup)Cancervs Noncancer<5 years postcancer treatment1.70 (1.31–2.21)
High-FAI by time after cancer treatment (subgroup)Cancervs Noncancer≥5 years postcancer treatment1.29 (0.87–1.92)

Overall population characteristics

Median age
70 years
Median fat attenuation index (FAI)
−75.8 HU

Original publication

Association Between Cancer Treatment History and Coronary Inflammation. JACC Adv. Published 19 November 2025. doi:10.1016/j.jacadv.2025.102333

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