Prevention & lipidsCross-sectional study
Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)
- Cross-sectional study
- population-based
- observational
Authors' conclusion
In a population without CVD or diabetes mellitus, impaired microvascular function is associated with cardiovascular risk profiles such as higher SCORE2 risk and CACS.
Study context
- Population
- Swedish adults aged 50–65 years in the SCAPIS cohort, without cardiovascular disease (CVD) or diabetes mellitus
- Participants
- 3,809 adults
- Exposure
- Lowest vs highest quartile of microvascular function
- Outcome
- Association of microvascular function (forearm skin peak blood oxygen saturation, OxyP) with CV risk (SCORE2) and subclinical atherosclerotic burden (CACS, carotid plaques)
Main finding
As reported in the abstract
SCORE2 (10-year risk of fatal and non-fatal CVD events)
Q1 vs Q4Odds ratio (95% CI)
SCORE2 > 10%; adjusted for BMI and high-sensitivity C-reactive protein
4.96(2.76–8.93)
- mean SCORE2
- relative risk increase 53%
Observational data: associations, not effects.
Further findings
OxyP by subclinical atherosclerotic burden
- OxyP by subclinical atherosclerotic burden — OxyP lower with CACS > 0 and with both carotid plaques and CACS > 0 vs no subclinical atherosclerotic burden
- P < 0.01
Original publication
Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study). Eur J Prev Cardiol. Published 9 February 2024. doi:10.1093/eurjpc/zwae052
Summarised from the published abstract; every number is checked against it