Heart failure & cardiomyopathiesCase-control study
Association between chronic kidney disease and heart failure across the ejection fraction spectrum: a retrospective case-control study from the Swedish Heart Failure Registry
- retrospective case-control study
- matched 1:1 by sex, year of birth, and county
Authors' conclusion
CKD was independently associated with new-onset HF, especially HFpEF in moderate to advanced CKD, and both HFpEF and HFrEF in mild CKD. Targeting CKD may be crucial to prevent HF.
Study context
- Population
- Patients with a first heart failure (HF) diagnosis from the Swedish HF Registry (2005–2021) and controls without HFHF patients, 51,848 controls · HF patients 51,848 · controls 51,848
- Participants
- 51,848 patients
- Comparison
- association between chronic kidney disease (CKD) and new-onset HF across the ejection fraction (EF) spectrum and according to CKD severity
- non-HFn = 51,848reference
Main finding
As reported in the abstract
HF by EF phenotype vs non-HF, CKD by ICD-10 definition
OR
- HFpEF
- 2.46
- HFmrEF
- 1.30
- HFrEF
- 1.52
Observational data: associations, not effects.
Further findings
HFpEF vs HFrEF, CKD by estimated glomerular filtration rate (eGFR) definition in the HF population
- higher odds of HFpEF vs HFrEF
- 8%
KDIGO stages (G2 as reference)
- G3b-G5 were more likely associated with HFpEF vs HFrEF
- G3a had similar associations with HFpEF and HFrEF
- G3a-G3b were less likely associated with HFmrEF vs. HFrEF
Original publication
Association between chronic kidney disease and heart failure across the ejection fraction spectrum: a retrospective case-control study from the Swedish Heart Failure Registry. ESC Heart Fail. Published 19 July 2026. doi:10.1093/eschf/xvag196
Summarised from the published abstract; every number is checked against it